Edna Mayo (March 23, 1895 – May 5, 1970) was an American film actress of the silent film era.Mayo was born in Philadelphia, Pennsylvania, moving to Hollywood to pursue an acting career in 1914. That year she received her first role, in the film Michael Arnold and Doctor Lynn opposite Robert Z. Leonard. Following that film, her career took off. In 1914 and 1915 she would star in twenty two films. However, in 1916 her career slowed at a fast pace, dwindling to only four film roles that year. It was over a year before she received another role, playing the female lead in Hearts of Love in 1918. It was her last film, and with no other roles coming her way, she retired from acting. She eventually settled in San Francisco, California, where she was residing at the time of her death on May 5, 1970.
Leading lady of the silent screen, on stage from 1906 and prominent in films with Essanay between 1914 and 1918. She was tagged as "the best-dressed film actress" with numerous publicity stills in McClure's, McCall's, Ladies World, and Pictorial Review. Her gowns were regularly designed by the couturier Lucile. Mayo also studied sculpture in New York at the Art Students League at the Art Institute in Chicago. Her career ended abruptly in 1918.